Diagnosis and Management of Paraneoplastic Neurologic Disorders
نویسندگان
چکیده
منابع مشابه
Paraneoplastic neurologic disorders: windows into neuronal function and tumor immunity.
Patients with PNDs typically exhibit rapidonset, severe, and focal neurologic disease on initial examination. Magnetic resonance imaging findings are usually normal, and medical history and physical examinations yield no obvious cause for the disorders. An occult malignancy is usually discovered as patients are followed up or when a PND diagnosis is suspected. It is believed that such malignanc...
متن کاملDiagnosis and treatment of paraneoplastic neurological disorders.
In about two thirds of cases, patients with paraneoplastic neurological disorders present to the neurologist without a known tumor. Due to the ongoing immune response, this tumor tends to stay biologically relatively benign, and therefore difficult to diagnose. In patients with a known tumor, the neurological symptoms often precede a tumor recurrence. In both scenarios, anti-neuronal antibodies...
متن کاملParaneoplastic Neurologic Disease
The term paraneoplastic neurologic disease (PND) encompasses several degenerative central or peripheral nervous system disorders that result from indirect effects of systemic cancer on elements of the nervous system. By definition, the dysfunction does not result from invasion or metastasis by tumor. The concept of a remote or indirect effect of cancer on the nervous system arose in the latter ...
متن کاملParaneoplastic neurologic syndromes.
Paraneoplastic neurologic syndromes are degenerative diseases of the central or peripheral nervous system that develop in association with a systemic neoplasm without a direct invasion by tumor. The pathogenesis of this disorder has been hypothesized in the past, and now there is increasing evidence that autoimmune processes triggered by the underlying neoplasm play a major role in the pathophy...
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ژورنال
عنوان ژورنال: Current Treatment Options in Oncology
سال: 2013
ISSN: 1527-2729,1534-6277
DOI: 10.1007/s11864-013-0249-1